Article: Exogenous brain-derived neurotrophic factor rescues synaptic dysfunction in Mecp2-null mice.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Kline DD; Ogier M; Kunze DL; Katz DM J. Neurosci., 2010
Structure | P35 Mecp2 wild type | P35 Mecp2 null versus wild type | ||
---|---|---|---|---|
BDNF-IR cell bodies | BDNF-IR processes | BDNF-IR cell bodies | BDNF-IR processes | |
Intermediate reticular nucleus | − | ++ | − | ↓↓↓ |
Gracile nucleus | − | + | − | ↓ |
Lateral reticular nucleus | − | ++ | − | ↓ |
Spinal trigeminal tract | − | ++ | − | ↓ |
Spinal trigeminal nucleus, caudal/interpolar | +++ | ++ | ↓ | ↓ |
Inferior olive | ++ | +++ | ↓ | ↓↓ |
Nucleus tractus solitarius | + | +++ | ↓ | ↓↓↓ |
Motor nucleus of the glossopharyngeal nerve | − | + | − | ↓ |
Motor nucleus of the vagus nerve | − | ++++ | − | ↓↓↓ |
Area postrema | +++ | ++ | ↓↓ | ↓↓↓ |
A1/C1 | − | ++ | − | ↓↓ |
Raphe obscurus | − | + | − | ↓ |
Nucleus ambiguus | − | ++ | − | ↓↓ |
Rostroventrolateral reticular nucleus | − | ++ | − | ↓↓↓ |
Ventral spinocerebellar tract | − | ++ | − | ↓ |
Parvocellular reticular nucleus | − | ++ | − | ↓ |
Prepositus nucleus | ++ | +/++ | ↓↓ | ↓ |
Raphe magnus | − | ++ | − | ↓ |
Lateral paragigantocellularis nucleus | − | ++ | − | ↓↓ |
Principal sensory nucleus of the trigeminal nerve, dorsomedial | − | +++ | − | ↓ |
Principal sensory nucleus of the trigeminal nerve, ventrolateral | ++ | − | ↓ | − |
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For BDNF-immunoreactive (IR) cell bodies: −, no cells observed; +, occasional cells; ++, scattered cells; +++, densely packed cells. For BDNF-IR cell processes: −, no processes observed; +, low density; ++, moderate density; +++, high density; ++++, very high density. For changes in null mice compared to wild types: −, no obvious change; ↓, mild decrease; ↓↓, moderate decrease; ↓↓↓, sharp decrease. Data was collected on three wild-type and three Mecp2-null mice.
Inferred neuron-electrophysiology data values
Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
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